From an unsponsored practicing physician

Which longevity interventions actually have human evidence?

A double board-certified internist reviewed 40+ interventions against the primary literature. Read the first chapter free.

No spam. Just the free chapter.

140+ peer-reviewed citations · No affiliate links · No supplement line · No sponsors
Dr. Ramy Khalil

Dr. Ramy Khalil

Double Board-Certified Internal Medicine.
Practicing in Dubai and the US.

The Problem

Don't let anybody fool you.

The best longevity protocols we have today are painfully unsexy. The things that actually work are boring, cheap, and don't make anyone money. The things that make money — exotic supplements, unproven peptides, expensive testing panels — have the weakest evidence. This playbook exists to tell you which is which.

What a typical longevity stack costs
NAD+ infusions$100
Supplement stack$70
Peptide injections$300
Biological age test$400
Per month$870/mo
What the evidence actually supports
Gym membership$50
Creatine$9
Vitamin D$5
Fish oil$12
Per month$76/mo
Inside the Playbook

Things you'll learn

01Most commercially available peptides have no human safety or efficacy trials
02There is a $20 blood test that predicts cardiovascular risk better than any $400 panel
03Why intermittent fasting may not be the longevity hack you think it is
04A free intervention that reduces all-cause mortality more than any supplement on the market
05Why cold plunges feel good but aren't extending your life
06The longevity paradox of taking growth hormone
07What I take every day, and what I deliberately don't

Every intervention gets a verdict

Here's a preview. The full playbook covers 40+ interventions with citations for every claim.

VO₂ Max Training

Each 1-MET increase = 13% lower all-cause mortality. Strongest single predictor of longevity.

Proven

NMN / NR

$1.2 billion market. Zero human lifespan extension trials completed to date.

Unproven

GLP-1 Agonists

20% CV event reduction in 17,604-patient RCT. Plus emerging cancer risk reduction signal.

Proven

BPC-157

Fewer than 30 humans ever studied. One clinical trial cancelled without explanation.

Insufficient Data

Sauna

4-7x/week = 63% lower sudden cardiac death. Observational but dose-dependent.

Promising

Rapamycin

Most interesting longevity drug in preclinical research. Not yet supported by human trial data.

Watching
What's Inside

13 sections. Every claim cited.

  1. 01The Things That Actually Work
  2. 02Supplements & Compounds
  3. 03Fasting & Dietary Protocols
  4. 04Peptides: The Wild West
  5. 05Cold & Heat Exposure
  6. 06Sleep
  7. 07Hormones
  8. 08Advanced Testing
  9. 09GLP-1/GIP Agonists
  10. 10The Supplement Deep-Dive
  11. 11Mindset & Social Connection
  12. 12My Personal Protocol
  13. 13Quarterly Updates
Expectations

An honest disclaimer

You won't find
  • Affiliate links to supplement companies
  • Dosing protocols for compounds
  • "Top 10 longevity hacks" listicles
  • Confidence whenever the topic calls for nuance
You will find
  • Every claim backed by a peer-reviewed citation you can verify
  • An honest "We don't know" whenever the data is not clear
  • A physician's personal protocol — including what he doesn't take
  • Clear verdicts: proven, promising, unproven, or skip
  • Quarterly updates as the science evolves — for life
About the Author

Ramy Khalil, MD

“The longevity industry is great at selling you a sexy narrative. My patients were spending hundreds of dollars a month on stuff that was either unproven or unsafe. I give them this resource to help guide our discussions on what's worth their time and money.”
Get Access

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$50

One-time purchase. Lifetime web access with quarterly updates included.

Less than one month of the supplements you might reconsider after reading the evidence.

  • Lifetime web access to the full playbook
  • All 13 sections with 140+ peer-reviewed citations
  • Personal protocol breakdown
  • Quarterly updates as new evidence emerges
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Questions

Before you read

Is this medical advice?+

No. This is one physician's evidence-based assessment. It's designed to help you make informed decisions with your own doctor.

What makes this different from free longevity content?+

Every claim has a numbered citation. There are no affiliate links, no sponsored products, and no financial incentive to recommend anything. My only conflict of interest is that I want you to read this.

How are quarterly updates delivered?+

Updated directly in the web version — included with your purchase for life. Each update covers what's been upgraded, downgraded, and newly on radar.

Can I get a refund?+

If the playbook doesn't change how you think about at least one intervention, I'll refund you within 30 days of purchase.

Do you sell supplements or run a longevity clinic?+

No. I run a direct primary care practice. Zero financial incentive to recommend any specific product.

Why are you charging for this? Shouldn't it be free?+

I don't have a supplement line. Nobody sponsored this or told me what to include or leave out. That's the point — and that's also why it costs something.

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Stop guessing. Start reading the data.

140+ citations. 13 sections. One internist's honest assessment of the evidence.

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