The Anti-Longevity PlaybookGet the Playbook
Evidence Review
Magnesium
Verdict
PromisingEvidence Tier
B
Moderate evidence
Human Studies
Yes — observational + supplementation
Typical Cost
$8-15/mo
Magnesium deficiency is common and under-recognized. Low serum magnesium is associated with increased cardiovascular risk, insulin resistance, and inflammation. Supplementation in deficient individuals improves these markers. At $8-15/month with an excellent safety profile, magnesium is one of the more reasonable supplements — particularly for those not meeting dietary intake.
The full evidence review — including why this cheap, common mineral might be the most underrated supplement in the longevity space — is in Section 10 (The Supplement Deep-Dive) of The Anti-Longevity Playbook.
Reviewed by Dr. Ramy Khalil, MD · Double Board-Certified Internal Medicine · Last updated March 2026
Is magnesium supplementation worth it?
Deficiency is common and linked to cardiovascular risk, insulin resistance, and inflammation. At $8-15/mo with an excellent safety profile, it's one of the more reasonable supplements.
Free Chapter
Want the full picture?
Start with a free chapter.
Read the first chapter of The Anti-Longevity Playbook free — including the intervention with stronger mortality data than Magnesium.
More from The Supplement Deep-Dive
Browse All Evidence Reviews
30+ longevity interventions reviewed by a physician against the primary literature.
ExerciseStatinsApoB TestingNMNNMN vs. NR — Which Is Better?ResveratrolRapamycinMetformin for LongevityBPC-157PeptidesCold Plunge / Cold ExposureSaunaSleepTestosterone Replacement TherapyGrowth HormoneContinuous Glucose MonitorFull-Body MRI ScreeningBiological Age TestsSemaglutideTirzepatideIntermittent FastingCaloric RestrictionBerberineOmega-3 Fatty AcidsVitamin DMagnesiumCoQ10SpermidineCreatineSocial ConnectionAlcohol