The Anti-Longevity PlaybookGet the Playbook
Evidence Review
Statins
Verdict
ProvenEvidence Tier
S
Strongest evidence
Human Studies
Yes — large RCTs
Typical Cost
$4/mo
Statins have some of the strongest randomized trial data of any preventive intervention. In high-risk patients, they reduce major cardiovascular events by 25-35%. The side effect profile is well-characterized after decades of use. At $4/month generic, the cost-effectiveness is unmatched by any supplement on the market.
The full evidence review — including the $4/month drug with stronger mortality data than most supplement stacks combined — is in Section 1 (The Things That Actually Work) of The Anti-Longevity Playbook.
Reviewed by Dr. Ramy Khalil, MD · Double Board-Certified Internal Medicine · Last updated March 2026
Do statins help with longevity?
Statins have robust RCT data showing 25-35% reduction in major cardiovascular events for high-risk patients. At $4/month, no supplement matches their cost-effectiveness for cardiovascular prevention.
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Read the first chapter of The Anti-Longevity Playbook free — including the intervention with stronger mortality data than Statins.
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