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Evidence Review
Testosterone Replacement Therapy (TRT)
Verdict
WatchingEvidence Tier
B
Moderate evidence
Human Studies
Yes — mixed results
Typical Cost
$50-200/mo
TRT reliably improves body composition, energy, and libido in men with clinically low testosterone. However, longevity effects are unclear. Some studies suggest cardiovascular benefit; others raise concerns. The TRAVERSE trial showed no increased cardiovascular risk but also no mortality benefit. TRT is not a longevity intervention — it's a hormone replacement for a deficiency state.
The full evidence review — including what the TRAVERSE trial actually showed and why TRT is a treatment, not a longevity hack — is in Section 7 (Hormones) of The Anti-Longevity Playbook.
Reviewed by Dr. Ramy Khalil, MD · Double Board-Certified Internal Medicine · Last updated March 2026
Does TRT improve longevity?
TRT improves symptoms in men with low testosterone, but the TRAVERSE trial showed no mortality benefit. It's a treatment for deficiency, not a longevity intervention.
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